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CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE syrup is a combination medication, indicated in the treatment of dry cough. They belong to the class of drugs called ‘cough and cold preparations’. Cough is a reactionary process of eliminating allergens, pollutants, and pathogens from the body. The dry cough is tickly and doesn’t produce any thick mucus.

The combination medicine comprises; Chlorpheniramine maleate (antihistamine), Phenylephrine hydrochloride (decongestant), and Dextromethorphan hydrobromide (cough suppressant). Chlorpheniramine maleate blocks the action of histamine, a substance that causes allergic reactions. Phenylephrine hydrochloride helps in shrinking the blood vessels located in the nasal passage reducing the stuffy nose. Dextromethorphan hydrobromide blocks the transmission of nerve signals from the cough center in the brain to the glands that produce cough. The synergetic effect of these drugs, therefore, provides relief from dry cough.

Take the medicine as per the dosage and duration prescribed by the doctor. Shake the syrup bottle before using it, to properly mix the ingredients. Some people may observe side effects like dry mouth, throat, or nose, drowsiness, blurred vision, constipation, dizziness, restlessness, or excitation. Usually, the side effects are transient and only last for a few days. Inform your doctor if you are allergic to any ingredient in the syrup or similar drugs. Pregnant and lactating women should stay cautious of the syrup and consume it only on the doctor’s recommendation.

Contraindication of CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE

Do not take this syrup if you have any of the following mentioned health conditions. It is advisable to consult the doctor and get recommendations on whether to use the medicine or not. The list of contraindications is given below:

• Taken monoamine oxidase inhibitors in the past 14 days
• Glaucoma
• Urinary problems
• Enlarged prostate
• Phenylketonuria (a congenital disability that causes accumulation of amino acid, phenylalanine in the body)
• Cough with mucus or cough caused by asthma
• Smoking
• Chronic bronchitis
• Emphysema (a lung condition causing shortness of breath)

Uses of CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE

The combination syrup is used in the treatment of Dry Cough.

Side Effects of CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE

The combination medicine has mild to temporary side effects that gradually resolve. The side effects are unique to each individual and depend on the environment and response to the medicines. If side effects get severe with time and worsen, immediately consult your doctor. The list of side effects is given below:

• Dry mouth, throat, or nose
• Drowsiness
• Dizziness
• Blurred vision
• Headache
• Constipation
• Restlessness or excitation
• Loss of appetite

Drug Interaction

When two different drugs are taken together, their combined effect may change how your medications work or increase your risk for serious side effects. Therefore, a particular should not be taken along with another drug, unless prescribed by a doctor.

Interaction with other medicines:

• Anti-allergic drugs (diphenhydramine)
• Anti-psychotic (escitalopram, desvenlafaxine, vilazodone)
• Pain killer (aspirin)
• Cold medicines (acetaminophen)
• Antibiotics (amoxicillin)
• Anti-depressants (linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine)
• Beta-blockers (metoprolol, atenolol)
• Muscle relaxants (carisoprodol, cyclobenzaprine)

Interaction with Food:

Avoid consuming the syrup with alcohol as it may increase the risk of drowsiness, dizziness or difficulty in concentrating.

Interaction with Disease:

• Liver or kidney disease
• Asthma
• Diabetes
• Glaucoma
• Cardiovascular diseases
• Enlarged prostate
• Chronic bronchitis
• Emphysema (a lung condition causing shortness of breath)

Precautions and Warning

1. Avoid consuming alcohol with this medicine, as it may cause increased drowsiness or dizziness.

2. Do not deviate from the dosage and strictly adhere to the duration prescribed by the doctor.

3. Keep the medicine out of reach of children and pets. Properly dispose of discarded and expired medicines.

4. Pregnant and lactating women should not take the syrup without consulting a doctor as it may impact the child.

5. Do not drive or perform any mental activity requiring you to concentrate as the syrup causes drowsiness and dizziness.

Frequently Asked Questions (FAQs)

1. Can I take CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE with anti-depressant medicines?

It is not recommended to take CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE along with any anti-depressant medication, especially MAO inhibitors (linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine), as it may lead to unpleasant side-effects or drug interaction.               

2. Can CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE be used in patients with glaucoma?

CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE may rarely worsen the symptoms of glaucoma. Therefore, CHLORPHENIRAMINE MALEATE+DEXTROMETHORPHAN HYDROBROMIDE+PHENYLEPHRINE HYDROCHLORIDE should be used with caution and only when prescribed by a doctor in patients with glaucoma.